Semaglutide

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Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes

Semaglutide, a glucagon-like peptide-1 receptor agonist, has been shown to reduce the risk of adverse cardiovascular events in patients with diabetes. Whether semaglutide can reduce cardiovascular risk associated with overweight and obesity in the absence of diabetes is unknown.

Sales soar at Danish firm behind weight-loss drug semaglutide

Semaglutide’s effects on obesity, with many patients experiencing more significant weight loss than with rival products, have made it into a rare medicine that has gained household recognition, with people ranging from billionaire Elon Musk to former prime minister Boris Johnson among those who have said they have taken the drug, which is administered via injections.

Semaglutide Trials Show Improvements in Cardiovascular Health, Quality of Life

In 2021, a landmark trial conducted at Northwestern Medicine found that the antidiabetic drug semaglutide was twice as effective in helping individuals lose weight than other weight-loss drugs on the market. Soon after the publication of these results, the drug — currently sold under the brand names Ozempic, Rybelsus and Wegovy — received the FDA’s approval for chronic weight management.