• Etilefrine hydrochloride

Etilefrine hydrochloride

  • CasNo:943-17-9
  • Purity:99%

Product Details;

CasNo: 943-17-9

Molecular Formula: C10H16ClNO2

Appearance: white

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  • Molecular Formula:C10H16ClNO2
  • Molecular Weight:217.696
  • Appearance/Colour:white 
  • Vapor Pressure:1.5E-05mmHg at 25°C 
  • Melting Point:122 °C 
  • Boiling Point:351.7 °C at 760 mmHg 
  • Flash Point:155.5 °C 
  • PSA:57.07000 
  • Density:1.127g/cm3 
  • LogP:-2.98710 

Etilefrine hydrochloride(Cas 943-17-9) Usage

Chemical Properties

White or almost white, crystalline powder or colourless crystals.


Circupon,Troponwerke,W. Germany


Adrenoceptor agonist.

Manufacturing Process

30 parts of 1-(3'-hydroxyphenyl)-2-(N-benzylaminomethyl)-ethan-1-one are mixed with 100 parts of pyridine and 30 parts of pivalic anhydride and dissolved while warming. After heating for 1 hour under reflux, the acylation is complete. After concentrating the reaction solution, the product is precipitated from acetone/ether. Yield: 96.4% of 1-(3'-pivaloyloxyphenyl)-2- (N-benzylaminomethyl)-ethan-1-one.3 parts of palladium/charcoal (10% strength) are prehydrogenated in water, thereafter 10 parts of 1-(3'-pivaloyloxyphenyl)-2-(N-benzylaminoethyl)-ethan- 1-one, dissolved in a 10-fold amount of water, are added dropwise at room temperature and hydrogenation is carried out until 1 mol of hydrogen has been taken up. After filtering off the catalyst, a further 3 parts of palladium/charcoal are added and hydrogenation is carried out until a further mol of hydrogen has been taken up. The catalyst is separated off and after removal of the solvent the hydrogenation product is reprecipitated from acetone/petroleum ether and from methanol/ether until it is pure according to thin layer chromatography. Yield: 38.8% of 1-(3'-pivaloyloxyphenyl)-2- ethylaminoethanol-1 hydroxide, melting point 208°C to 209°C.

Therapeutic Function



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