2-(1H-indol-3-yl)ethanamine

Description

2-(1H-indol-3-yl)ethanamine, commonly known as tryptamine, is a monoamine alkaloid with a structure derived from the amino acid tryptophan.

Synthesis

2-(1H-indol-3-yl)ethanamine can be synthesized by the decarboxylation of the amino acid tryptophan.

Natural Sources

2-(1H-indol-3-yl)ethanamine is found in various living organisms, including fungi, plants, Amphibia, animals, and microbes.

Biosynthesis

In plants, 2-(1H-indol-3-yl)ethanamine plays a role in a biosynthetic pathway leading to the plant hormone indole-3-acetic acid.

Neurotransmitter and Neuromodulator

2-(1H-indol-3-yl)ethanamine is present in small amounts in the mammalian brain, where it acts as a modulator or neurotransmitter. It is involved in the release of serotonin agents and enhances serotonergic activity.

Psychedelic Properties

2-(1H-indol-3-yl)ethanamine is known for its psychedelic effects, and it is associated with alterations in cognition, sleep, temperature regulation, memory, and behavior.

Mammalian Brain

The compound is naturally found in the mammalian brain in trace amounts.

Traditional Use

Indigenous Amazonian tribes have traditionally used tryptamine-containing brews for therapeutic purposes, addressing physical maladies and substance abuse disorders.