• Diethyl(phenylacetyl)malonate

Diethyl(phenylacetyl)malonate

  • CasNo：20320-59-6
  • Purity：99%

Product Details;

CasNo： 20320-59-6

Molecular Formula： C15H18O5

Buy Reliable Quality 20320-59-6 with Low Price and Efficient Transportation

  • Molecular Formula:C15H18O5
  • Molecular Weight:278.305
  • Boiling Point:120 °C(Press: 0.01 Torr) 
  • PKA:8.76±0.59(Predicted) 
  • PSA：69.67000 
  • Density:1.148±0.06 g/cm3(Predicted) 
  • LogP:1.54060 

20320-59-6 Relevant articles

Comprehensive study on excited state intramolecular proton transfer in 2-(benzo[d]thiazol-2-yl)-3-methoxynaphthalen-1-ol and 2-(benzo[d]thiazol-2-yl)naphthalene-1,3-diol: Effect of solvent, aggregation, viscosity and TDDFT study

Warde, Umesh,Nagaiyan, Sekar

, p. 33 - 43 (2017)

Three compounds DMT, MMT and DHT having ...

The Interrupted Pummerer Reaction in a Sulfoxide-Catalyzed Oxidative Coupling of 2-Naphthols

He, Zhen,Pulis, Alexander P.,Procter, David J.

supporting information, p. 7813 - 7817 (2019/05/15)

A benzothiophene S-oxide catalyst, gener...

INDOLIN-2-ONE DERIVATIVES AS PROTEIN KINASE INHIBITORS

-

Paragraph 0283, (2013/11/05)

A novel class of indoline-2-one derivati...

Novel Inhibitors of Hepatitis C Virus Replication

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Page/Page column 52-53, (2009/10/21)

The embodiments provide compounds of the...

20320-59-6 Process route

phenylacetyl chloride
103-80-0

phenylacetyl chloride

diethyl malonate
105-53-3

diethyl malonate

diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

Conditions
Conditions Yield
diethyl malonate; With ethanol; magnesium; In tetrachloromethane; toluene; for 1h; Heating;
phenylacetyl chloride; In tetrachloromethane; toluene; at 20 ℃; for 1h;
90%
With chloroform; magnesium;
 
With magnesium;
 
With sodium;
 
Multistep reaction; (i) Mg, EtOH, (ii) /BRN= 742254/;
 
diethyl malonate; With triethylamine; magnesium chloride; In acetonitrile; at 0 ℃; for 0.5h; Inert atmosphere;
phenylacetyl chloride; In acetonitrile; at 20 ℃;
 
With magnesium; In ethanol; toluene; at 80 ℃;
 
diethyl malonate; With sodium hydride; In tetrahydrofuran; for 1h;
phenylacetyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;
489 mg
ethanol
64-17-5

ethanol

2,2-dimethyl-5-(2-phenylacetyl)-1,3-dioxane-4,6-dione
74965-87-0

2,2-dimethyl-5-(2-phenylacetyl)-1,3-dioxane-4,6-dione

diethyl 2-(2-phenylacetyl)malonate
20320-59-6

diethyl 2-(2-phenylacetyl)malonate

Conditions
Conditions Yield
for 3h; Reflux;
 

20320-59-6 Upstream products

  • 996-82-7
    996-82-7

    sodium diethylmalonate

  • 103-80-0
    103-80-0

    phenylacetyl chloride

  • 105-53-3
    105-53-3

    diethyl malonate

  • 570-08-1
    570-08-1

    diethyl acetylmalonate

20320-59-6 Downstream products

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    621-06-7

    2,N-diphenylacetamide

  • 20280-94-8
    20280-94-8

    4-benzyl-7-hydroxycoumarin

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    101981-93-5

    Naphthalin-2-sulfonsaeure-<1-benzyl-2,2-diaethoxycarbonyl-vinyl-ester>

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    91614-52-7

    2-benzyl-3-ethoxycarbonyl-7-methylpyrazolo<5,1-b><1,3>oxazin-5(5H)-one

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