What is the β-ESTRADIOL?

β-ESTRADIOL is white crystalline powder, while it's Molecular Formula is C18H24O2. white crystalline powder Estradiol USP (Estrace) is used to treat Breast cancer; prostatic carcinoma.

What is the CAS number for β-ESTRADIOL?

The CAS number of β-ESTRADIOL is 50-28-2.

What is β-ESTRADIOL (50-28-2) used for?

β-Estradiol is an endogenous estrogenic hormone receptor (ER) agonist (Ki values are 0.12 and 0.13 nM for ERα and ERβ respectively). Also high affinity ligand at membrane estrogen GPR30 receptors. β-Estradiol is an activator of PI 3-kinase.Estradiol (17β-estradiol, β-Estradiol, E2, 17β-Oestradiol) is a human sex hormone and steroid, and the primary female sex hormone. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.InChI:InChI=1/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m0/s1

What is the β-ESTRADIOL?

β-ESTRADIOL is white crystalline powder, while it's Molecular Formula is C18H24O2. white crystalline powder Estradiol USP (Estrace) is used to treat Breast cancer; prostatic carcinoma.

What is the CAS number for β-ESTRADIOL?

The CAS number of β-ESTRADIOL is 50-28-2.

What is β-ESTRADIOL (50-28-2) used for?

β-Estradiol is an endogenous estrogenic hormone receptor (ER) agonist (Ki values are 0.12 and 0.13 nM for ERα and ERβ respectively). Also high affinity ligand at membrane estrogen GPR30 receptors. β-Estradiol is an activator of PI 3-kinase.Estradiol (17β-estradiol, β-Estradiol, E2, 17β-Oestradiol) is a human sex hormone and steroid, and the primary female sex hormone. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.InChI:InChI=1/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m0/s1

Offer 50-28-2 with Reasonable Price, Factory Supply 50-28-2

Product Details;

CasNo： 50-28-2

Molecular Formula： C₁₈H₂₄O₂

Appearance： white crystalline powder

Offer 50-28-2 with Reasonable Price, Factory Supply 50-28-2

Molecular Formula:C18H24O2
Molecular Weight:272.387
Appearance/Colour:white crystalline powder
Vapor Pressure:9.82E-09mmHg at 25°C
Melting Point:178-179 °C(lit.)
Refractive Index:80.4 ° (C=1, Dioxane)
Boiling Point:445.917 °C at 760 mmHg
PKA:pKa 10.71±0.02(H2O(0.1% p-dioxane) t=25±0.1 I=0.03(KCl))(Approximate)
Flash Point:209.634 °C
PSA：40.46000
Density:1.17 g/cm³
LogP:3.60920

β-ESTRADIOL(Cas 50-28-2) Usage

Description	β-Estradiol, also known as 17β-estradiol, E2, or 17β-Oestradiol, is a critical human sex hormone and steroid that serves as the primary female sex hormone. β-Estradiol is a fundamental hormone with diverse functions in the female reproductive system. Its role extends beyond reproductive health, influencing bone health and other physiological processes.
Contradictions	Do not use on breasts, vaginal area and vaginal mucosa.
Uses	Functions as an endogenous estrogenic hormone receptor (ER) agonist. Exhibits high affinity for both ERα and ERβ receptors (Ki values are 0.12 and 0.13 nM for ERα and ERβ, respectively). Plays a crucial role in various physiological processes, including the regulation of the menstrual cycle, development of reproductive tissues, and maintenance of bone health.
Medical Applications	Used for in vitro maturation of bovine cumulus-oocyte complexes (COCs). Implicated in hormone replacement therapy (HRT) for postmenopausal women.
Definition	ChEBI: The 17beta-isomer of estradiol.
Hazard	A carcinogen (OSHA).
Shipping	UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials
Who Evaluation	Evaluation year: 2000

InChI:InChI=1/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m0/s1

50-28-2 Relevant articles

β-Estradiol Reduces Natural Killer Cells in Mice

William E. Seaman; Marcia A. Blackman; Thomas D. Gindhart; Jirayr R. Roubinian; John M. Loeb; Norman Talal

, J Immunol (1978) 121 (6): 2193–2198.

Androgen (5α-dihydrotestosterone) did not. Castration of male or female mice did not affect natural killing and did not alter the effect of β-estradiol. Estradiol did not affect natural killing in vitro and the loss of natural killing was not due to a soluble or a cellular suppressor of natural killing.

In vitro modulation of β-estradiol-induced vitellogenin synthesis: Effects of cytochrome P4501A1 inducing compounds on rainbow trout (Oncorhynchus mykiss) liver cells

Michael J. Anderson a ∗, Michael R. Miller b, David E. Hinton a

, Aquatic Toxicology Volume 34, Issue 4, April 1996, Pages 327-350

At 10−8 M, congener 114, a weak EROD inducer, potentiated Vg synthesis relative to cells treated with β-estradiol alone.

Mechanism of action of bolandiol (19-nortestosterone-3β,17β-diol), a unique anabolic steroid with androgenic, estrogenic, and progestational activities

Attardi, Barbara J.,Page, Stephanie T.,Hild, Sheri A.,Coss, Christopher C.,Matsumoto, Alvin M.

, p. 151 - 161 (2010)

Bolandiol is a synthetic anabolic steroi...

50-28-2 Process route

: 63-05-8
Androstenedione

: 50-28-2
estradiol

: 53-16-7
Estrone

: 58-22-0
testosterone

: 521-18-6
Stanolone

: 53-42-9
Etiocholanolone

: 53-41-8
cis-androsterone

Conditions

Conditions	Yield
With carcinoma; gynecomastia; mammary dysplasia; at 37 ℃; for 1.5h; Product distribution; cofactors under 95percent O2: 5percent CO2, <3H>labeled study;