• β-ESTRADIOL

β-ESTRADIOL

  • CasNo:50-28-2
  • Purity:99%

Product Details;

CasNo: 50-28-2

Molecular Formula: C18H24O2

Appearance: white crystalline powder

Offer 50-28-2 with Reasonable Price, Factory Supply 50-28-2

  • Molecular Formula:C18H24O2
  • Molecular Weight:272.387
  • Appearance/Colour:white crystalline powder 
  • Vapor Pressure:9.82E-09mmHg at 25°C 
  • Melting Point:178-179 °C(lit.) 
  • Refractive Index:80.4 ° (C=1, Dioxane) 
  • Boiling Point:445.917 °C at 760 mmHg 
  • PKA:pKa 10.71±0.02(H2O(0.1% p-dioxane) t=25±0.1 I=0.03(KCl))(Approximate) 
  • Flash Point:209.634 °C 
  • PSA:40.46000 
  • Density:1.17 g/cm3 
  • LogP:3.60920 

β-ESTRADIOL(Cas 50-28-2) Usage

Description

β-Estradiol, also known as 17β-estradiol, E2, or 17β-Oestradiol, is a critical human sex hormone and steroid that serves as the primary female sex hormone. β-Estradiol is a fundamental hormone with diverse functions in the female reproductive system. Its role extends beyond reproductive health, influencing bone health and other physiological processes.

Contradictions

Do not use on breasts, vaginal area and vaginal mucosa.

Uses

Functions as an endogenous estrogenic hormone receptor (ER) agonist.
Exhibits high affinity for both ERα and ERβ receptors (Ki values are 0.12 and 0.13 nM for ERα and ERβ, respectively).
Plays a crucial role in various physiological processes, including the regulation of the menstrual cycle, development of reproductive tissues, and maintenance of bone health.

Medical Applications Used for in vitro maturation of bovine cumulus-oocyte complexes (COCs).
Implicated in hormone replacement therapy (HRT) for postmenopausal women.

Definition

ChEBI: The 17beta-isomer of estradiol.

Hazard

A carcinogen (OSHA).

Shipping

UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials

Who Evaluation

Evaluation year: 2000

InChI:InChI=1/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m0/s1

50-28-2 Relevant articles

β-Estradiol Reduces Natural Killer Cells in Mice

William E. Seaman; Marcia A. Blackman; Thomas D. Gindhart; Jirayr R. Roubinian; John M. Loeb; Norman Talal

, J Immunol (1978) 121 (6): 2193–2198.

Androgen (5α-dihydrotestosterone) did not. Castration of male or female mice did not affect natural killing and did not alter the effect of β-estradiol. Estradiol did not affect natural killing in vitro and the loss of natural killing was not due to a soluble or a cellular suppressor of natural killing.

In vitro modulation of β-estradiol-induced vitellogenin synthesis: Effects of cytochrome P4501A1 inducing compounds on rainbow trout (Oncorhynchus mykiss) liver cells

Michael J. Anderson a ∗, Michael R. Miller b, David E. Hinton a

, Aquatic Toxicology Volume 34, Issue 4, April 1996, Pages 327-350

At 10−8 M, congener 114, a weak EROD inducer, potentiated Vg synthesis relative to cells treated with β-estradiol alone.

Mechanism of action of bolandiol (19-nortestosterone-3β,17β-diol), a unique anabolic steroid with androgenic, estrogenic, and progestational activities

Attardi, Barbara J.,Page, Stephanie T.,Hild, Sheri A.,Coss, Christopher C.,Matsumoto, Alvin M.

, p. 151 - 161 (2010)

Bolandiol is a synthetic anabolic steroi...

50-28-2 Process route

Androstenedione
63-05-8

Androstenedione

estradiol
50-28-2

estradiol

Estrone
53-16-7

Estrone

testosterone
58-22-0

testosterone

Stanolone
521-18-6

Stanolone

Etiocholanolone
53-42-9

Etiocholanolone

cis-androsterone
53-41-8

cis-androsterone

Conditions
Conditions Yield
With carcinoma; gynecomastia; mammary dysplasia; at 37 ℃; for 1.5h; Product distribution; cofactors under 95percent O2: 5percent CO2, <3H>labeled study;
 
17β-estradiol 3'-(saccharinylmethyl) ether
157231-19-1

17β-estradiol 3'-(saccharinylmethyl) ether

formaldehyd
50-00-0,30525-89-4,61233-19-0

formaldehyd

estradiol
50-28-2

estradiol

saccharin
81-07-2

saccharin

Conditions
Conditions Yield
With phosphate buffer; water; In methanol; at 37 ℃; Rate constant; various pH-values (4.98-7.98); half-life; other media, other temperature;
 

50-28-2 Upstream products

  • 91-22-5
    91-22-5

    quinoline

  • 846-48-0
    846-48-0

    1-dehydrotestosterone

  • 99-35-4
    99-35-4

    1,3,5-trinitrobenzene

  • 53-16-7
    53-16-7

    Estrone

50-28-2 Downstream products

  • 1474-52-8
    1474-52-8

    17β-oestradiol diacetate

  • 1743-60-8
    1743-60-8

    17-β-estradiol 17-acetate

  • 24381-12-2
    24381-12-2

    2-iodo-17β-oestradiol

  • 15833-07-5
    15833-07-5

    2-bromo-17β-oestradiol

Inquiry

Name:
*CompanyName:
*Email:
*Requirements:
*Code:
Submit