CasNo： 77591-33-4
Molecular Formula： C212H350N56O78S
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Thymosin β-4 is an endogenous pro-angiogenic, fibroblast-activating peptide that is involved in hormone regulation. Thymosin β-4 also exhibits immunomodulatory and cardioprotective activities. Thymosin β-4 improves would healing in cardiac issue and improves cardiac function in vivo. Thymosin β-4 binds G-actin filaments, preventing actin polymerization.
The CAS number of Thymosin beta 4 acetate is 77591-33-4.
Synonyms for Thymosin beta 4 acetate 77591-33-4:Thymosinb4 (ox);L-Serine,N-acetyl-L-seryl-L-a-aspartyl-L-lysyl-L-prolyl-L-a-aspartyl-L-methionyl-L-alanyl-L-a-glutamyl-L-isoleucyl-L-a-glutamyl-L-lysyl-L-phenylalanyl-L-a-aspartyl-L-lysyl-L-seryl-L-lysyl-L-leucyl-L-lysyl-L-lysyl-L-threonyl-L-a-glutamyl-L-threonyl-L-glutaminyl-L-a-glutamyl-L-lysyl-L-asparaginyl-L-prolyl-L-leucyl-L-prolyl-L-seryl-L-lysyl-L-a-glutamyl-L-threonyl-L-isoleucyl-L-a-glutamyl-L-glutaminyl-L-a-glutamyl-L-lysyl-L-glutaminyl-L-alanylglycyl-L-a-glutamyl-;Peptide Fx (humanblood platelet);Thymosin b4 (Gekko gekko liver);Thymosin b4 (human);Thymosin b4 (rat);Thymosin β4 Acetate;Thymosin b4 (cattle);
Thymosin beta 4 acetate, also known as Tβ4, is a peptide with diverse physiological effects. It is an endogenous pro-angiogenic and fibroblast-activating peptide involved in hormone regulation. With immunomodulatory and cardioprotective properties, Tβ4 has been shown to enhance wound healing in cardiac tissue and improve cardiac function in vivo. Widely distributed in the body, Tβ4 plays a pivotal role in processes such as angiogenesis, proliferation, apoptosis inhibition, and inflammation suppression.
Relevant articles related to Thymosin beta 4 acetate:
| Tβ4 Is Not a Simple G-actin Sequestering Protein and Interacts with F-actin at High Concentration (∗) |
PROTEIN CHEMISTRY AND STRUCTURE| VOLUME 271, ISSUE 16, P9231-9239, APRIL 1996 Tβ4 behaves as a simple G-actin sequestering protein only in a range of low concentrations (<20 μM). As the concentration of Tβ4 increases, its ability to depolymerize F-actin decreases, due to its interaction with F-actin. The Tβ4-actin can be incorporated, in low molar ratios, into F-actin, and can be cross-linked in F-actin using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide. |
| Tβ4 Increases Neovascularization and Cardiac Function in Chronic Myocardial Ischemia of Normo- and Hypercholesterolemic Pigs |
Molecular Therapy, 2018 In this study, we investigated the impact of thymosin β4 (Tβ4), which promotes collateralization and capillarization, during hypercholesterolemia, a known risk factor of coronary artery disease. Initial in vitro results highlighted an improved endothelial cell function upon Tβ4 treatment under control conditions and during hypercholesterolemic stress (scratch area [pixels]: oxidized low-density lipoprotein [oxLDL], 191,924 ± 7,717; and oxLDL + Tβ4, 105,621 ± 11,245). |
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